In addition, 5 of 383 decedents met the requirements for frailty, advanced dementia, and organ failing. Of the 57 decedents categorized as having another condition, the underlying cause of death was ischemic cardiovascular disease in 36.8 percent, infection in 19.3 percent, and stroke in 14.4 percent. The distribution of the disability trajectories according to the condition resulting in death is shown in Figure 2Figure 2Distribution of Disability Trajectories within the last Year of Life, According to Condition Resulting in Death among the 383 Decedents.The researchers could actually isolate and capture the beta-arrestin1 protein within an active state since it binds to a segment of the GPCR – an initial. That snapshot, in high res, revealed that the structural conformation or shape of the proteins in its active condition is strikingly unique of when it is inactive. Such changes suggest there could be a general molecular system that activates the beta-arrestin1 – sort of main switch that handles the multi-useful signaling proteins. ‘It's like generally there are brakes on in beta-arrestin1, and when the beta-arrestin1 binds to a GPCR after that, the brakes are released, thereby activating beta-arrestin1,’ said Arun K.