In the present study, the analysis of the human was cystathionase gene promoter reveals the presence of an inverted repeat sequence. Administration of an FXR ligand carbon tetrachloride carbon tetrachloride-treated mice to down-regulation of expression cystathionase increased hydrogen sulfide generation decreased portal pressure and attenuated endothelial dysfunction of the isolated and perfused livers. symptoms male infertility
In summary, they CSE CSE is an FXR – regulated gene. By linking the deficiency of CSE to the FXR activity in the present study provides a new molecular explanation for the pathophysiology of portal hypertension. Also proposes the concept that FXR agonists might for the altered generation of endogenous hepatic vasodilators takes place to correct in chronic liver diseases.
The work of Prof. Touitou a worldwide authority within the drug delivery area is focused on the shaping of new carriers for improved drug absorption and efficient. Two start-up companies were created and are not running in in developing various novel pharmaceutical items, based on prescribed previously developed innovative technology. This innovative drug delivery systems a powerful tool that allows the development of better drugs for the treatment of pain, said Lorenzo Pradella, Business and Operational Development Director by Z-Cube. Patients with pains are out of to this new approach, which extended and easier to create agents benefits promise use. .