Van Dijk, M.D., Ph.D., Joost de Vries, M.D., Ph.D., Paul L.M. De Kort, M.D., Ph.D., Willem Jan J. Van Rooij, M.D., Ph.D., Jan S.P. Van den Berg, M.D., Ph.D., Boudewijn A.A.M. Van Hasselt, M.D., Leo A.M. Aerden, M.D., Ph.D. Dallinga, M.D., Marieke C. Visser, M.D., Ph.D., Joseph C.J. Bot, M.D., Ph.D., Patrick C. Vroomen, M.D., Ph.D., Omid Eshghi, M.D., Tobien H.C.M.L. Schreuder, M.D., Roel J.J. Heijboer, M.D., Koos Keizer, M.D., Ph.D., Alexander V. Tielbeek, M.D., Ph.D., Heleen M.The game is intended to be an alternative to smoking cigarettes with the goal of reducing or getting rid of tobacco use in players’ lives. The overall game involves breathing into a microphone to control gameplay and is coupled with sound, color, images, feedback and challenges to mimic the stimulant and relaxant effects of smoking. Effects will end up being evaluated through psychological response and physiological methods , heart rate, galvanic epidermis response) and in comparison to subjects after cigarette smoking or after playing the game in lieu of smoking.