The use of plasma exchange was well balanced between the groups . Two sufferers in the rituximab group received a third dosage of cyclophosphamide: one was classified as having a treatment failure; the various other, who had a reply to the rituximab regimen and received the 3rd cyclophosphamide dose in violation of the process, was categorized as having effective treatment. Major Outcomes Sustained Remission Sustained remission happened in 25 of 33 patients in the rituximab group and 9 of 11 sufferers in the control group .68). Six sufferers in the rituximab group and 1 patient in the control group died within the 1st 12 weeks. Among the patients who survived, 93 percent of the sufferers in the rituximab group and 90 percent of the patients in the control group got sustained remission .‘When it became clear that Williams Syndrome can be caused by a microdeletion of genes, we could start looking at smaller sized and smaller gene deletions to study their effect on interpersonal behavior.’ Two genes in particular, GTF2I and GTF2IRD1, caught Korenberg’s eyes. Both encode transcription factors that help regulate the activity of various other genes. Although their precise function is unidentified, the genes are active in lots of body tissues and appear to be particularly important in regulating brain and skeletal muscles genes.