However, the researchers discovered that on rat versions affected by chronic stress, nectin-3 molecules were reduced in number significantly. It had been known that chronic stress causes an enormous release of glutamate currently, a molecule that acts on NMDA receptors, which are essential for synaptic plasticity and therefore for memory. What these experts found is these receptors activated the MMP-9 enzymes which now, like scissors, literally cut the nectin-3 cell adhesion proteins. ‘At these times, nectin-3 becomes unable to perform its part as a modulator of synaptic plasticity’ described Carmen Sandi. In turn, these effects lead topics to reduce their sociability, avoid interactions with their peers and also have impaired storage or understanding.That is why today, Allergan is certainly announcing the REFRESH AMERICA marketing campaign to help our nation's best perform and alleviate their discomfort from dry eyesight. Every buy of specially-marked deals in the REFRESH OPTIVE®product line between 8/1/15 – 7/31/16 will lead to donations of REFRESH®eye drops to choose first responder organizations nationwide. Allergan guarantees a minimum item donation with an approximate retail worth of $250,000, regardless of the accurate number of eligible products sold through the campaign period. Logo design -ttp://photos.prnewswire.com/p. ‘We are delighted that we can provide comfort to initial responders working in smoky and dusty circumstances with quality eye maintenance systems,’ said Brent Saunders, CEO, Allergan.